Close Menu
The LinkxThe Linkx
  • Home
  • Technology
    • Gadgets
    • IoT
    • Mobile
    • Nanotechnology
    • Green Technology
  • Trending
  • Advertising
  • Social Media
    • Branding
    • Email Marketing
    • Video Marketing
  • Shop

Subscribe to Updates

Get the latest tech news from thelinkx.com about tech, gadgets and trendings.

Please enable JavaScript in your browser to complete this form.
Loading
What's Hot

This Thiel-backed venture allows doping in its own sports

October 15, 2025

Machine learning helps identify ‘thermal switch’ for next-generation n…

October 15, 2025

Apple doesn't include a charger in the box with the new M5 MacBoo…

October 15, 2025
Facebook X (Twitter) Instagram
Facebook X (Twitter) Instagram Pinterest Vimeo
The LinkxThe Linkx
  • Home
  • Technology
    • Gadgets
    • IoT
    • Mobile
    • Nanotechnology
    • Green Technology
  • Trending
  • Advertising
  • Social Media
    • Branding
    • Email Marketing
    • Video Marketing
  • Shop
The LinkxThe Linkx
Home»Nanotechnology»Spatiotemporal-adaptive nanotherapeutics promote post-injury regenerat…
Nanotechnology

Spatiotemporal-adaptive nanotherapeutics promote post-injury regenerat…

Editor-In-ChiefBy Editor-In-ChiefOctober 1, 2025No Comments7 Mins Read
Share Facebook Twitter Pinterest LinkedIn Tumblr Reddit Telegram Email
Spatiotemporal-adaptive nanotherapeutics promote post-injury regenerat…
Share
Facebook Twitter LinkedIn Pinterest Email


  • Sabine et al. Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026–1030 (2017).

    Article 

    Google Scholar
     

  • Rodríguez-Morales, P. & Franklin, R. A. Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis. Trends Immunol. 44, 986–998 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jones, D. L. & Wagers, A. J. No place like home: anatomy and function of the stem cell niche. Nat. Rev. Mol. Cell Biol. 9, 11–21 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Ogrodnik, M. & Gladyshev, V. N. The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations. Nat. Aging 3, 766–775 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hazeldine, J., Lord, J. M. & Hampson, P. Immunesenescence and inflammaging: a contributory factor in the poor outcome of the geriatric trauma patient. Ageing Res. Rev. 24, 349–357 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Wei, T. et al. Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds. Nat. Nanotechnol. 19, 1–12 (2024).

    Article 
    CAS 

    Google Scholar
     

  • Ambrosi, T. H. et al. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature 597, 256–262 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lei, Q. et al. Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration. Sci. Transl. Med. 13, eaaz8697 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Villa, C. et al. Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle. Nat. Nanotechnol. 19, 1532–1543 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, Y. et al. Nutrient-delivery and metabolism reactivation therapy for melanoma. Nat. Nanotechnol. 19, 1399–1408 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • Hu, X. et al. An artificial metabzyme for tumour-cell-specific metabolic therapy. Nat. Nanotechnol. 19, 1712–1722 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pålsson-McDermott, E. M. & O’Neill, L. A. J. Targeting immunometabolism as an anti-inflammatory strategy. Cell Res. 30, 300–314 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cai, Y. et al. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell 30, 1674–1691.e8 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Covarrubias, A. J., Perrone, R., Grozio, A. & Verdin, E. NAD+ metabolism and its roles in cellular processes during ageing. Nat. Rev. Mol. Cell Biol. 22, 119–141 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Verdin, E. NAD+ in aging, metabolism, and neurodegeneration. Science 350, 1208–1213 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang, H. et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352, 1436–1443 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Minhas, P. S. et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation. Nat. Immunol. 20, 50–63 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yeung, F. et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369–2380 (2004).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Trammell, S. A. J. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat. Commun. 7, 12948 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu, Y. et al. Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis. Sci. Adv. 8, eadd3599 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fang, R. H., Gao, W. & Zhang, L. Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat. Rev. Clin. Oncol. 20, 33–48 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Liu, Y., Zhao, Y. & Chen, X. Bioengineering of metal-organic frameworks for nanomedicine. Theranostics 9, 3122–3133 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang, K. et al. Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules. Nat. Commun. 6, 7240 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wynn, T. A. & Vannella, K. M. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44, 450–462 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Freemerman, A. J. et al. Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J. Biol. Chem. 289, 7884–7896 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Neill, L. A. J., Kishton, R. J. & Rathmell, J. A guide to immunometabolism for immunologists. Nat. Rev. Immunol. 16, 553–565 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Runtsch, M. C. et al. Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metab. 34, 487–501.e8 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496, 238–242 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yan, J. & Horng, T. Lipid metabolism in regulation of macrophage functions. Trends Cell Biol. 30, 979–989 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Remmerie, A. & Scott, C. L. Macrophages and lipid metabolism. Cell Immunol. 330, 27–42 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Di Gioia, M. et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat. Immunol. 21, 42–53 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • O’Neill, L. A. J. & Hardie, D. G. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493, 346–355 (2013).

    Article 
    PubMed 

    Google Scholar
     

  • Vats, D. et al. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab. 4, 13–24 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Andreux, P. A., Houtkooper, R. H. & Auwerx, J. Pharmacological approaches to restore mitochondrial function. Nat. Rev. Drug Discov. 12, 465–483 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sun, N. et al. Measuring in vivo mitophagy. Mol. Cell 60, 685–696 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yan, C. et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy 16, 419–434 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mouchiroud, L. et al. The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430–441 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gaharwar, A. K., Singh, I. & Khademhosseini, A. Engineered biomaterials for in situ tissue regeneration. Nat. Rev. Mater. 5, 686–705 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Rodier, F. et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973–979 (2009).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lozano-Torres, B. et al. The chemistry of senescence. Nat. Rev. Chem. 3, 426–441 (2019).

    Article 
    CAS 

    Google Scholar
     

  • Liang, K. et al. In situ biomimetic mineralization of bone-like hydroxyapatite in hydrogel for the acceleration of bone regeneration. ACS Appl. Mater. Interfaces 15, 292–308 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chao, Y., Chen, Q. & Liu, Z. Smart injectable hydrogels for cancer immunotherapy. Adv. Funct. Mater. 30, 1902785 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Lu, Y.-Z. et al. CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature 628, 604–611 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Calcinotto, A. et al. Cellular senescence: aging, cancer, and injury. Physiol. Rev. 99, 1047–1078 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gao, C. et al. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat. Commun. 11, 2622 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fang, R. H. et al. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale 5, 8884–8888 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kallai, I. et al. Microcomputed tomography–based structural analysis of various bone tissue regeneration models. Nat. Protoc. 6, 105–110 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Martino, M. M. et al. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science 343, 885–888 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     



  • Source link

    Drug delivery general Materials Science Nanoparticles Nanotechnology Nanotechnology and Microengineering nanotherapeutics postinjury Promote regenerat.. Spatiotemporaladaptive Tissue engineering and regenerative medicine
    Share. Facebook Twitter Pinterest LinkedIn Tumblr Email
    Previous ArticleOmnitron’s MEMS Tech Boosts Lidar Reliability
    Next Article Galaxy Ring’s swollen battery incident raises safety concerns for user…
    Editor-In-Chief
    • Website

    Related Posts

    Nanotechnology

    Machine learning helps identify ‘thermal switch’ for next-generation n…

    October 15, 2025
    Nanotechnology

    Scientists grow metal instead of 3D printing it — and it’s 20x stronge…

    October 14, 2025
    Advertising

    The One Show Launches Indies Discipline to Spotlight Independent Agenc…

    October 14, 2025
    Add A Comment
    Leave A Reply Cancel Reply

    Top Posts

    100+ TikTok Statistics Updated for December 2024

    December 4, 202487 Views

    How to Fix Cant Sign in Apple Account, Verification Code Not Received …

    February 11, 202566 Views

    Cisco Automation Developer Days 2025

    February 10, 202522 Views
    Stay In Touch
    • Facebook
    • YouTube
    • TikTok
    • WhatsApp
    • Twitter
    • Instagram
    Latest Reviews

    Subscribe to Updates

    Get the latest tech news from thelinkx.com about tech, gadgets and trendings.

    Please enable JavaScript in your browser to complete this form.
    Loading
    About Us

    Welcome to TheLinkX – your trusted source for everything tech and gadgets! We’re passionate about exploring the latest innovations, diving deep into emerging trends, and helping you find the best tech products to suit your needs. Our mission is simple: to make technology accessible, engaging, and inspiring for everyone, from tech enthusiasts to casual users.

    Our Picks

    This Thiel-backed venture allows doping in its own sports

    October 15, 2025

    Machine learning helps identify ‘thermal switch’ for next-generation n…

    October 15, 2025

    Apple doesn't include a charger in the box with the new M5 MacBoo…

    October 15, 2025

    Subscribe to Updates

    Get the latest tech news from thelinkx.com about tech, gadgets and trendings.

    Please enable JavaScript in your browser to complete this form.
    Loading
    • About Us
    • Contact Us
    • Disclaimer
    • Privacy Policy
    • Terms and Conditions
    © 2025 Thelinkx.All Rights Reserved Designed by Prince Ayaan

    Type above and press Enter to search. Press Esc to cancel.