Guo YJ, Wang XY, Li BB, Shen Y, Shen LY, Wu JX, Yang J. Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering. J Biomed Mater Res B Appl Biomater. 2022;110:2667–75.
Hisham F, Akmal MHM, Ahmad F, Ahmad K, Samat N. Biopolymer chitosan: potential sources, extraction methods, and emerging applications. Ain Shams Eng J. 2024, 15.
Pan XH, Li R, Li WY, Sun W, Yan YY, Xiang XC, Fang JH, Liao YG, Xie C, Wang XZ et al. Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears. Nat Commun. 2024, 15.
Sun J, Xiao LL, Li B, Zhao KL, Wang ZL, Zhou Y, Ma C, Li JJ, Zhang HJ, Herrmann A, Liu K. Genetically engineered polypeptide adhesive coacervates for surgical applications. Angew Chem Int Ed. 2021;60:23687–94.
Wang HH, Wang MX, Wu JH, Zhu SL, Ye YA, Liu YS, Li K, Li RY, Zhang YH, Wei M et al. Nature-inspired gelatin-based adhesive hydrogel: A rapid and user-friendly solution for hemostatic applications. Adv Healthc Mater. 2024.
Tarafder S, Park GY, Felix J, Lee CH. Bioadhesives for musculoskeletal tissue regeneration. Acta Biomater. 2020;117:77–92.
Nakipoglu M, Tezcaner A, Contag CH, Annabi N, Ashammakhi N. Bioadhesives with antimicrobial properties. Adv Mater. 2023, 35.
Zhu J, Zhou HL, Gerhard EM, Zhang SH, Rodríguez FIP, Pan TS, Yang HB, Lin Y, Yang J, Cheng HY. Smart bioadhesives for wound healing and closure. Bioact Mater. 2023;19:360–75.
Chen XM, Zhang J, Chen GD, Xue Y, Zhang JJ, Liang XY, Lei EM, Lin JS, Xu BB, Liu J. Hydrogel bioadhesives with extreme acid-tolerance for gastric perforation repairing. Adv Funct Mater. 2022, 32.
Singh M, Nanda HS, Lee JYH, Wang JK, Tan NS, Steele TWJ. Photocurable platelet rich plasma bioadhesives. Acta Biomater. 2020;117:133–41.
Barapatre A, Meena AS, Mekala S, Das A, Jha H. In vitro evaluation of antioxidant and cytotoxic activities of lignin fractions extracted from Acacia nilotica. Int J Biol Macromol. 2016;86:443–53.
Xue J, Wang D, Li XJ, Li GC, Wang Z, Liu YS, Li XB. A tandem strategy of mild preoxidation-hydrogenolysis for efficient depolymerization of lignin. Mol Catal. 2023, 549.
Sharifi M, Pothu R, Boddula R. Inamuddin. Lignin to value-added chemical synthesis. Curr Anal Chem. 2021;17:936–46.
Song CY, Gao C, Fatehi P, Wang SJ, Jiang CB, Kong FG. Influence of structure and functional group of modified kraft lignin on adsorption behavior of dye. Int J Biol Macromol. 2023, 240.
Singh M, Lee SC, Won K. Lignin phenolation by graft copolymerization to boost its reactivity. Int J Biol Macromol. 2024, 266.
Figueiredo P, Lintinen K, Hirvonen JT, Kostiainen MA, Santos HA. Properties and chemical modifications of lignin: towards lignin-based nanomaterials for biomedical applications. Prog Mater Sci. 2018;93:233–69.
Shao Y, Xia QN, Dong L, Liu XH, Han X, Parker SF, Cheng YQ, Daemen LL, Ramirez-Cuesta AJ, Yang SH, Wang YQ. Selective production of Arenes via direct lignin upgrading over a niobium-based catalyst. Nat Commun. 2017, 8.
Martim DB, Brilhante A, Lima AR, Paixao DAA, Martins J Jr., Kashiwagi FM, Wolf LD, Costa MS, Menezes FF, Prata R et al. Resolving the metabolism of monolignols and other lignin-related aromatic compounds in Xanthomonas citri. Nat Commun. 2024, 15.
Sugiarto S, Leow Y, Tan CL, Wang G, Kai D. How Far is lignin from being a biomedical material? Bioact Mater. 2022;8:71–94.
Dong L, Wang YQ, Dong YG, Zhang Y, Pan MZ, Liu XH, Gu XL, Antonietti M, Chen ZP. Sustainable production of dopamine hydrochloride from softwood lignin. Nat Commun. 2023, 14.
Sapouna I, Alexakis AE, Malmström E, McKee LS. Structure-property relationship of native-like lignin nanoparticles from softwood and hardwood. Ind Crops Prod. 2023, 206.
Wang TP, Li H, Yuan JM, Li WX, Li K, Huang YB, Xiao LP, Lu Q. Structures and pyrolytic characteristics of organosolv lignins from typical softwood, hardwood and herbaceous biomass. Ind Crops Prod. 2021, 171.
Vigh M. A trashed treasure: lignin could become a large and renewable source of organic compounds for the chemical industry to replace fossil fuel-based chemicals. EMBO Rep. 2023, 24.
Bajwa DS, Pourhashem G, Ullah AH, Bajwa SG. A concise review of current lignin production, applications, products and their environmental impact. Ind Crops Prod. 2019;139:111526.
Weidener D, Holtz A, Klose H, Jupke A, Leitner W, Grande PM. Lignin precipitation and fractionation from organocat pulping to obtain lignin with different sizes and chemical composition. Molecules. 2020, 25.
Sun RC. Lignin source and structural characterization. Chemsuschem. 2020;13:4385–93.
Dessbesell L, Paleologou M, Leitch M, Pulkki R, Xu C. Global lignin supply overview and kraft lignin potential as an alternative for petroleum-based polymers. Renew Sustainable Energy Reviews. 2020, 123.
Söderholm K, Bergquist AK. Growing green and Competitive-A case study of a Swedish pulp mill. Sustainability. 2013;5:1789–805.
UPM Biochemicals. https://www.upmbiochemicals.com. Accessed 10 June 2025.
Borregaard. https://www.borregaard.com/product-areas/lignin. Accessed 10 June 2025.
Domsjö. https://www.domsjo.adityabirla.com/produkter/lignin/. Accessed 10 June 2025.
Stora Enso. https://www.storaenso.com/en/products/bio-based-materials/neoligno-by-stora-enso. Accessed 10 June 2025.
Escalante FME, Carranza-Hernández A, García-Zamora A, Aguilar-Garnica E. Optimization of lignin-based biocatalyst production from pine sawdust and wheat straw. Molecules. 2018, 23.
Bécsy-Jakab VE, Savoy A, Saulnier BK, Singh SK, Hodge DB. Extraction, recovery, and characterization of lignin from industrial corn Stover lignin cake. Bioresour Technol. 2024, 399.
Huang YX, Peng LL, Liu Y, Zhao GJ, Chen JY, Yu GH. Biobased nano porous active carbon fibers for high-performance supercapacitors. ACS Appl Mater Interfaces. 2016;8:15205–15.
Mainka H, Täger O, Körner E, Hilfert L, Busse S, Edelmann FT, Herrmann AS. Lignin – an alternative precursor for sustainable and cost-effective automotive carbon fiber. J Mater Res Technol. 2015;4:283–96.
Webber MS, Watson J, Zhu J, Jang JH, Çaglayan M, Heyne JS, Beckham GT, Róman-Leshkov Y. Lignin deoxygenation for the production of sustainable aviation fuel blendstocks. Nat Mater. 2024;23:1622–38.
Prakash VRA, Bourchak M, Alshahrani H, Juhany KA. Synthesis and characterization of lightweight unmanned aerial vehicle composite Building material for defense application. Biomass Convers Biorefin. 2023.
Dorieh A, Pahlavan F, Hájková K, Hysek S, Pour MF, Fini EH. Advancing sustainable Building materials: reducing formaldehyde emissions in medium density fiber boards with lignin nanoparticles. Adv Sustain Syst. 2024, 8.
Liu SC, Xin X, He ZJ, Xie ZH, Xie ZX, Liu ZH, Li BZ, Yuan YJ. Biological conversion of lignin-derived ferulic acid from wheat Bran into Vanillin. Int J Biol Macromol. 2024, 281.
Song J, He YN, Luo CH, Feng B, Ran F, Xu H, Ci ZM, Xu RC, Han L, Zhang DK. New progress in the Pharmacology of Protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily. Pharmacol Res. 2020, 161.
Liu B, Li CP, Wang WQ, Song SG, Liu XM. Lignans extracted from Eucommia ulmoides oliv. Protects against AGEs-induced retinal endothelial cell injury. Cell Physiol Biochem. 2016;39:2044–54.
Moussaoui Y, Ferhi F, Elaloui E, Ben Salem R, Belgacem MN. Utilization of Astragalus armatus roots in papermaking. BioResources. 2011;6:4969–78.
Leventis TE, Judge P, Zhang JL, Kazmi MZH, Foston MB, Williams FJ. Boron Lewis acid extraction of wood generates high quality lignin. ACS Sustain Chem Eng. 2024;12:17210–21.
Bakshi MI, Nazir S, Restu WK, Rajamanickam R, Selvasembian R, Hua LS, Antov P, Yadav KK, Abbas M, Farobie O, Fatriasari W. Recent advances in lignin from forest residue for hydrogel application. Biomass Convers Biorefin. 2024.
Carvajal JC, Gómez A, Cardona CA. Comparison of lignin extraction processes: economic and environmental assessment. Bioresour Technol. 2016;214:468–76.
Dong X, Shang J, Xiao TY, Song R, Sheng XR, Li N, Zhang J, Ping QW. A facile method to fabricate sustainable bamboo ethanol lignin/carboxymethylcellulose films with efficient anti-ultraviolet and insulation properties. Int J Biol Macromol. 2024, 273.
Sun D, Wang B, Wang HM, Li MF, Shi QT, Zheng L, Wang SF, Liu SJ, Sun RC. Structural transformations of hybrid Pennisetum lignin: effect of microwave-assisted hydrothermal pretreatment. ACS Sustain Chem Eng. 2019;7:3073–82.
Rao KCA, Nair CS. Combination of ensemble machine learning models in photocatalytic studies using nano TiO2-lignin based Biochar. Chemosphere. 2024;352:141326.
De Saegher T, Deroma M, Atanasova B, Van Geem KM, De Clercq J, Lauwaert J, Verberckmoes A. Maximizing the valorization potential of lignin through optimization of the soda pulping conditions. Sep Purif Technol. 2025, 354.
Mao YJ, Gerrow A, Ray E, Perez ND, Edler K, Wolf B, Binner E. Lignin recovery from cocoa bean shell using microwave-assisted extraction and deep eutectic solvents. Bioresour Technol. 2023, 372.
Mohammadabadi SI, Javanbakht V. Lignin extraction from barley straw using ultrasound-assisted treatment method for a lignin-based biocomposite Preparation with remarkable adsorption capacity for heavy metal. Int J Biol Macromol. 2020;164:1133–48.
Shen XJ, Huang PL, Wen JL, Sun RC. A facile method for Char elimination during base-catalyzed depolymerization and hydrogenolysis of lignin. Fuel Process Technol. 2017;167:491–501.
Aro T, Fatehi P. Production and application of lignosulfonates and sulfonated lignin. Chemsuschem. 2017;10:1861–77.
Agwu KA, Ekeoma BC, Enguita JM, Daymude JW, Bara JE, Sheehan JD. Glycerol-derived solvents for tractable organosolv extraction of softwood lignins. ACS Sustain Chem Eng. 2024;12:15089–102.
Sebhat W, El Roz A, Fongarland P, Vilcocq L, Djakovitch L. Catalytic liquefaction of kraft lignin with solvothermal approach. Catalysts. 2021, 11.
Vishtal A, Kraslawski A. Challenges in industrial applications of technical lignins. BioResources. 2011;6:3547–68.
Dhara S, Samanta NS, Uppaluri R, Purkait MK. High-purity alkaline lignin extraction from Saccharum ravannae and optimization of lignin recovery through response surface methodology. Int J Biol Macromol. 2023, 234.
Lugovitskaya TN, Kolmachikhina EB. Associative behavior of lignosulfonates in moderately concentrated water, water-salt, and water-alcoholic media. Biomacromolecules. 2021;22:3323–31.
Kumar N, Vijayshankar S, Pasupathi P, Kumar SN, Elangovan P, Rajesh M, Tamilarasan K. Optimal extraction, sequential fractionation and structural characterization of soda lignin. Res Chem Intermed. 2018;44:5403–17.
Dababi I, Gimello O, Elaloui E, Quignard F, Brosse N. Organosolv lignin-based wood adhesive: influence of the lignin extraction conditions on the adhesive performance. Polymers. 2016, 8.
Thoresen PP, Lange HK, Crestini C, Rova U, Matsakas L, Christakopoulos P. Characterization of organosolv Birch lignins: toward application-specific lignin production. ACS Omega. 2021;6:4374–85.
Zheng JY, Chen LH, Qiu XQ, Liu YC, Qin YL. Structure investigation of light-colored lignin extracted by Lewis acid-based deep eutectic solvent from softwood. Bioresour Technol. 2023, 385.
Nardella F, Prothmann J, Sandahl M, Spégel P, Ribechini E, Turner C. Native lignin extraction from soft- and hardwood by green and benign sub/supercritical fluid extraction methodologies. RSC Adv. 2023;13:21945–53.
Pérez E, Tuck CO, Poliakoff M. Valorisation of lignin by depolymerisation and fractionation using supercritical fluids and conventional solvents. J Supercrit Fluids. 2018;133:690–5.
Li Man ZX, Huahui Z, Xiangxiang W. Research progress on ionic liquid extraction technology in extracting effective components of Chinese medicine. World J Tradit Chin Med. 2023;18:2541–7.
Miao CL, Xinshu Z, Yang LM, Li HW, Lv PM, Luo W. Study on extraction of lignin and synthesis of lignin-based epoxy resins using ionic liquid. Biomass Convers Biorefin. 2023;13:1115–26.
Ciolacu F, Malutan T, Lisa G, Ichim M. Influence of lignin type on the properties of hemp fiber-reinforced polypropylene composites. Polymers. 2024, 16.
Johansson M, Skrifvars M, Kadi N, Dhakal HN. Effect of lignin acetylation on the mechanical properties of lignin-poly-lactic acid biocomposites for advanced applications. Ind Crops Prod. 2023, 202.
Greco R, Tiburcio E, Palomar-De Lucas B, et al. Click amidations, esterifications and one–pot reactions catalyzed by Cu salts and multimetal–organic frameworks (M–MOFs). Mol Catal. 2022;522:112228.
Heble AY, Chen C. Access to advanced functional materials through postmodification of biomimetic assemblies via click chemistry. Biomacromolecules. 2024;25(3):1391–407.
An. l, chen j, heo jw, bae jh, jeong h, kim ys. Synthesis of lignin-modified cellulose nanocrystals with antioxidant activity via diels–alder reaction and its application in carboxymethyl cellulose film. Carbohydrate polymers. 2021. 274: 118651.
Zhang duan. f, su y, wang m, wang j. Effects of ultrasonic-alkali integrated extraction combined with mannesi reaction on the antimicrobial properties of rice straw lignin and enhancement strategies. International journal of biological macromolecules. 2025. 284: 138047.
Liu b. Shao x, Kang z, Cheng h, Hu d. Sustainable lignin-driven homogenization of microarchitecture in improving tio2 dye-sensitized photoanode. J Power Sources. 2025;644:237142.
Wu r. Liu w, Li z, Hou q. Revealing adsorption of mixed enzymes onto Lignin resulted from integration of hydrothermal and chemi-mechanical pretreatment. Ind Crops Prod. 2023;194:116353.
Quesada-salas et al. mc, vuillemin me, dillies j,. 1-ethyl-3-methyl imidazolium acetate, hemicellulolytic enzymes and laccase-mediator system: toward an integrated co-valorization of polysaccharides and lignin from miscanthus. Industrial crops and products. 2023. 197: 116627.
Kim KH, Jeong K, Zhuang JS, Jeong HJ, Kim CS, Koo B, Yoo CG. Tandem conversion of lignin to catechols via demethylation and catalytic hydrogenolysis. Ind Crops Prod. 2021;159.
Yan GH, Chen GF, Peng ZQ, Shen ZL, Tang X, Sun Y, Zeng XH, Lin L. The cross-linking mechanism and applications of catechol-metal polymer materials. Adv Mater Interfaces. 2021;8.
Marcelo G, López-González M, Trabado I, Rodrigo MM, Valiente M, Mendicuti F. Lignin-inspired PEG hydrogels for drug delivery. Mater Today Commun. 2016;7:73–80.
Jia ZR, Zeng Y, Tang PF, Gan DL, Xing WS, Hou Y, Wang KF, Xie CM, Lu X. Conductive, tough, transparent, and self-healing hydrogels based on catechol-metal ion dual self-catalysis. Chem Mater. 2019;31:5625–32.
Wu HS, Sariola V, Zhao JS, Ding HJ, Sitti M, Bettinger CJ. Composition-dependent underwater adhesion of catechol-bearing hydrogels. Polym Int. 2016;65:1355–9.
Afewerki S, Wang XC, Ruiz-Esparza GU, Tai CW, Kong XY, Zhou SY, Welch K, Huang P, Bengtsson R, Xu C, Strömme M. Combined catalysis for engineering bioinspired, lignin-based, long-lasting, adhesive, self-mending, antimicrobial hydrogels. ACS Nano. 2020;14:17004–17.
Chen LH, Li T, Qiu XQ, Qin YL. Amino acid-modified lignin combined with methylation to form novel pH-responsive colloidal spheres with tunable properties. ACS Sustain Chem Eng. 2024;12:5052–60.
Hajirahimkhan S, Xu CC, Ragogna PJ. Ultraviolet curable coatings of modified lignin. ACS Sustain Chem Eng. 2018;6:14685–94.
Yu XN, Chen SS, Wang WC, Deng TS, Wang HL. Empowering alkali lignin with high performance in Pickering emulsion by selective phenolation for the protection and controlled-release of agrochemical. J Clean Prod. 2022;339.
Korich AL, Fleming AB, Walker AR, Wang JF, Tang CB, Iovine PM. Chemical modification of organosolv lignin using boronic acid-containing reagents. Polymer. 2012;53:87–93.
Deng PP, Chen FX, Zhang HD, Chen Y, Zhou JP. Conductive, self-healing, adhesive, and antibacterial hydrogels based on lignin/cellulose for rapid MRSA-infected wound repairing. ACS Appl Mater Interfaces. 2021;13:52333–45.
Nardi M, Ceseracciu L, Scribano V, Contardi M, Athanassiou A, Zych A. Sustainable adhesives: exploring boronic ester vitrimers containing lignin microparticles. Chem Eng J. 2024;495.
Wang DF, Shan YT, Liu L, Diao MY, Yao JM. Lignin demethylation enabled robust and reprocessable bio-polyurethane elastomer with adaptable cross-linking network. Ind Crops Prod. 2024;208.
Ahadyani N, Abdollahi M. Phenolation, amination and cross-linking of lignin: synthesis and characterization of functionalized lignin. Polym Bull. 2024;81:8643–61.
Dinu R, Cantarutti C, Mija A. Design of sustainable materials by cross-linking a biobased epoxide with keratin and lignin. ACS Sustain Chem Eng. 2020;8:6844–52.
Anghel N, Melinte V, Spiridon I, Pertea M. Antioxidant, antimicrobial, and kinetic studies of β-cyclodextrin crosslinked with lignin for drug delivery. Pharmaceutics. 2022;14.
Srivastava A, Manu, Gupta RK. Xanthan gum and lignin grafted chemically crosslinked hydrogels for dye removal: synthesis, characterization and isotherms studies. Polym Sci Ser A. 2023;65:725–33.
Huang ZY, Wang H, Du JH, Liu XC, Pan GY, Yin XS, Lin WJ, Lin XF, Sun YJ, Yi GB, Niu L. High-strength, self-reinforcing and recyclable multifunctional lignin-based polyurethanes based on multi-level dynamic cross-linking. Chem Eng J. 2023;473.
Andriani F, Lawoko M. Oxidative carboxylation of lignin: exploring reactivity of different lignin types. Biomacromolecules. 2024;25:4246–54.
Zhang YJ, Wang H, Eberhardt TL, Gu Q, Pan H. Preparation of carboxylated lignin-based epoxy resin with excellent mechanical properties. Eur Polym J. 2021;150.
Qian Y, Zhou YJ, Lu MJ, Guo XS, Yang DJ, Lou HM, Qiu XQ, Guo CAF. Direct construction of catechol lignin for engineering long-acting conductive, adhesive, and UV-blocking hydrogel bioelectronics. Small Methods. 2021;5.
Zheng T, Zheng DF, Li XK, Cai C, Lou HM, Liu WF, Qiu XQ. Synthesis of quaternized lignin and its clay-tolerance properties in montmorillonite-containing cement paste. ACS Sustain Chem Eng. 2017;5:7743–50.
Ye XX, Luo W, Lin L, Zhang YQ, Liu MH. Quaternized lignin-based dye dispersant: characterization and performance research. J Dispers Sci Technol. 2017;38:852–9.
Wang YY, Wang H, Li ZX, Yang DJ, Qiu XQ, Liu YC, Yan MZ, Li Q. Fabrication of litchi-like lignin/zinc oxide composites with enhanced antibacterial activity and their application in polyurethane films. J Colloid Interface Sci. 2021;594:316–25.
Wang YQ, Chen MJ, Yang Y, Ralph J, Pan XJ. Efficient O-demethylation of lignin-derived aromatic compounds under moderate conditions. RSC Adv. 2023;13:5925–32.
Sawamura K, Tobimatsu Y, Kamitakahara H, Takano T. Lignin functionalization through chemical demethylation: Preparation and tannin-like properties of demethylated guaiacyl-type synthetic lignins. ACS Sustain Chem Eng. 2017;5:5424–31.
Liu HL, Chung HY. Visible-light induced thiol-ene reaction on natural lignin. ACS Sustain Chem Eng. 2017;5:9160–8.
Belgodere JA, Son DW, Jeon B, Choe J, Guidry AC, Bao AX, Zamin SA, Parikh UM, Balaji S, Kim M, Jung JP. Attenuating fibrotic markers of patient-derived dermal fibroblasts by thiolated lignin composites. ACS Biomater Sci Eng. 2021;7:2212–8.
Paananen H, Alvila L, Pakkanen TT. Hydroxymethylation of softwood kraft lignin and phenol with paraformaldehyde. Sustain Chem Pharm. 2021;20.
Malutan T, Nicu R, Popa VI. Contribution to the study of hydroxymethylation reaction of alkali lignin. BioResources. 2008;3:13–20.
Pang J, Meng LZ, Huang HT, Ma J, He LL, Huang P. Decorated gold nanoparticles on hydroxymethylated lignin modified magnetic composite: introducing a novel therapeutic drug for the treatment of renal anemia. Inorg Chem Commun. 2023;153.
de Oliveira DR, Avelino F, Mazzetto SE, Lomonaco D. Microwave-assisted selective acetylation of kraft lignin: acetic acid as a sustainable reactant for lignin valorization. Int J Biol Macromol. 2020;164:1536–44.
Zhao XH, Huang ZQ, Zhang YJ, Yang M, Chen D, Huang K, Hu HY, Huang AM, Qin XZ, Feng ZF. Efficient solid-phase synthesis of acetylated lignin and a comparison of the properties of different modified lignins. J Appl Polym Sci. 2017;134.
Maldonado-Carmona N, Ouk TS, Villandier N, Calliste CA, Calvete MJF, Pereira MM, Leroy-Lhez S. Photophysical and antibacterial properties of porphyrins encapsulated inside acetylated lignin nanoparticles. Antibiot (Basel). 2021;10.
Abdulkhani A, Khorasani Z, Hamzeh Y, Momenbeik F, Zadeh ZE, Sun FB, Madadi M, Zhang XM. Valorization of Bagasse alkali lignin to water-soluble derivatives through chemical modification. Biomass Convers Biorefin. 2024;14:8639–47.
Al-Horani RA, Aliter KF. Triple action of lignosulfonic acid sodium: Anti-protease, antioxidant, and anti-inflammatory effects of a polymeric heparin mimetic. Med Chem. 2024;20:414–21.
Zhao CK, Li SX, Zhang H, Yue FX, Lu FC. Structural insights into the alkali lignins involving the formation and transformation of arylglycerols and enol ethers. Int J Biol Macromol. 2020;152:411–7.
Zhou HZ, Li JY, Ma EN. Multiscale modification of Populus Cathayana by alkali lignin combined with heat treatment. Polymers. 2018;10.
Zhou YJ, Qian Y, Wang JY, Qiu XQ, Zeng HB. Bioinspired lignin-polydopamine nanocapsules with strong bioadhesion for long-acting and high-performance natural sunscreens. Biomacromolecules. 2020;21:3231–41.
Yan L, Huertas-Alonso AJ, Liu H, Dai L, Si C, Sipponen MH. Lignin polymerization: towards high-performance materials. Chem Soc Rev. 2025 Jun;10.
Guo HD, Cao MN, Liu RX, Tian B, Liu SX, Li J, Li SJ, Strehmel B, James TD, Chen ZJ. Photocured room temperature phosphorescent materials from lignosulfonate. Nat Commun. 2024;15.
Michalek L, Mundsinger K, Barner-Kowollik C, Barner L. The long and the short of polymer grafting. Polym Chem. 2019;10:54–9.
Tobita H. Effect of small reaction locus in free-radical polymerization: conventional and reversible-deactivation radical polymerization. Polymers. 2016;8.
Santos CCO, Ferreira V, Pinheiro F, Lona IF. Lignin valorization through polymer grafting by ring-opening polymerization and its application in health, packaging, and coating. J Environ Chem Eng. 2023;11(3):109691.
Najarro MC, Nikolic M, Iruthayaraj J, Johannsen I. Tuning the Lignin-Caprolactone copolymer for coating metal surfaces. ACS Appl Polym MaterialsACS Appl Polym MaterialsACS Appl Polym Mater. 2020;2(12):5767–78.
Tian J, Yang Y, Song J. Grafting Polycaprolactone onto alkaline lignin for improved compatibility and processability. Int J Biol Macromol. 2019;141:919–26.
Li Y, Wang XN, Han YY, Sun HY, Hilborn J, Shi LY. Click chemistry-based biopolymeric hydrogels for regenerative medicine. Biomed Mater. 2021;16.
Wahan SK, Bhargava G, Chawla PA. Harnessing click chemistry for the discovery of fluorescent materials. Dyes Pigm. 2024;222.
Devaraj NK, Finn MG. Introduction: click chemistry. Chem Rev. 2021;121:6697–8.
Dudchak R, Podolak M, Holota S, Szewczyk-Roszczenko O, Roszczenko P, Bielawska A, Lesyk R, Bielawski K. Click chemistry in the synthesis of antibody-drug conjugates. Bioorg Chem. 2024;143.
An RR, Liu CG, Wang J, Jia PY. Wood-derived polymers from olefin-functionalized lignin and Ethyl cellulose via thiol-ene click chemistry. Polymers. 2023;15.
Jin YJ, Joshi M, Araki T, Kamimura N, Masai E, Nakamura M, Michinobu T. Click synthesis of Triazole polymers based on lignin-derived metabolic intermediate and their strong adhesive properties to Cu plate. Polymers. 2023;15.
Han YM, Yuan L, Li GY, Huang LH, Qin TF, Chu FX, Tang CB. Renewable polymers from lignin via copper-free thermal click chemistry. Polymer. 2016;83:92–100.
An LL, Chen J, Heo JW, Bae JH, Jeong H, Kim YS. Synthesis of lignin-modified cellulose nanocrystals with antioxidant activity via Diels-Alder reaction and its application in carboxymethyl cellulose film. Carbohydr Polym. 2021;274.
Wang HX, Mai YA, Qiu WL, Liu WF, Yang DJ, Fang ZQ, Qiu XQ. Water-, oil-, and stain-resistant lignin-based degradable waterborne polyurethane for paper packaging coating. ACS Sustain Chem Eng. 2025.
Heble AY, Chen CL. Access to advanced functional materials through postmodification of biomimetic assemblies via click chemistry. Biomacromolecules. 2024;25:1391–407.
Sougrati L, Duval A, Avérous L. Introducing phenol-yne chemistry for the design of lignin-based vitrimers: towards sustainable and recyclable materials. J Mater Chem A. 2025.
Ciferri MC, Bruno S, Rosenwasser N, Gorgun C, Reverberi D, Gagliani MC, Cortese K, Grange C, Bussolati B, Quarto R, Tasso R. Standardized method to functionalize plasma-extracellular vesicles via copper-free click chemistry for targeted drug delivery strategies. ACS Appl Bio Mater. 2024;7:827–38.
Yoon HY, Lee D, Lim DK, Koo H, Kim K. Copper-free click chemistry: applications in drug delivery, cell tracking, and tissue engineering. Adv Mater. 2022;34:e2107192.
Kim E, Koo H. Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo. Chem Sci. 2019;10:7835–51.
Kim JY, Hwang H, Oh S, Kim YS, Kim UJ, Choi JW. Investigation of structural modification and thermal characteristics of lignin after heat treatment. Int J Biol Macromol. 2014;66:57–65.
Gu LH, Jiang B, Song JL, Jin YC, Xiao HN. Effect of lignin on performance of lignocellulose nanofibrils for durable superhydrophobic surface. Cellulose. 2019;26:933–44.
Gilca IA, Popa VI, Crestini C. Obtaining lignin nanoparticles by sonication. Ultrason Sonochem. 2015;23:369–75.
Xu J, Krietemeyer EF, Boddu VM, Liu SX, Liu WC. Production and characterization of cellulose nanofibril (CNF) from agricultural waste corn Stover. Carbohydr Polym. 2018;192:202–7.
Xia QQ, Chen CJ, Yao YG, He SM, Wang XZ, Li JG, Gao JL, Gan WT, Jiang B, Cui MJ, Hu LB. In situ lignin modification toward photonic wood. Adv Mater. 2021;33.
Kumar A, Kumar GA. Modification of lignin properties using alpha particles and gamma-rays for diverse applications. Radiat Phys Chem. 2023;202.
Ingti pi K, Choudhury BJ, Moholkar VS. Ultrasound assisted lignin-decorated MWCNT doped flexible PVA-Chitosan composite hydrogel. Mater Today Commun. 2023;35.
Liza AA, Wang SH, Zhu YC, Wu H, Guo LK, Qi YG, Zhang FS, Song JL, Ren H, Guo JQ. Ultraviolet (UV) assisted fabrication and characterization of lignin containing cellulose nanofibrils (LCNFs) from wood residues. Int J Biol Macromol. 2024;283.
Chen SL, Shao QZ, Hu L, Tan ZR, Zheng DF. Hydrophobic and magnetic fabrication of hydroxyethyl cellulose-lignin aerogel through ultrasound enhancement for efficient oil/water separation. J Water Process Eng. 2023;52.
Fang L, Yazdi S, Frazier CE. Catalytic acidolysis: impact on in situ pine-lignin repolymerization. ACS Sustain Chem Eng. 2023;11:10709–16.
Wang X, Xu WB, Zhang D, Li XY, Shi JY. Structural characteristics-reactivity relationships for catalytic depolymerization of lignin into aromatic compounds: A review. Int J Mol Sci. 2023;24.
Civzele A, Stipniece-Jekimova AA, Mezule L. Fungal ligninolytic enzymes and their application in biomass lignin pretreatment. J Fungi. 2023;9.
Xu WH, Zhou CW, Hu K, Yang JW, Su WK, Qiao P. Novel mechanoenzymatic strategy for lignin depolymerization. Ind Eng Chem Res. 2023;62:19448–58.
Qiu W, Liu J. Fermenting and lignin degradability of a white-rot fungus coriolopsis trogii using industrial lignin as substrate. Appl Biochem Biotechnol. 2022;194:5220–35.
Chen HY, Liang XY, Li SZ, Cui ZL, Yong YC, Ni Z, Bu Q, Zhu DC. Straw lignin degradation by lignin peroxidase from Irpex lacteus cooperated with enzymes and small molecules. Biotechnol Lett. 2023;45:95–104.
Chen HY, Li SZ, Cui ZL, Feng T, Wang HC, Ni Z, Gao EB, Fang Z. Synergistic degradation of maize straw lignin by manganese peroxidase from Irpex lacteus. Appl Biochem Biotechnol. 2023;195:3855–71.
Zhu DC, Liang N, Zhang RX, Ahmad F, Zhang WM, Yang B, Wu J, Geng A, Gabriel M, Sun JZ. Insight into depolymerization mechanism of bacterial laccase for lignin. ACS Sustain Chem Eng. 2020;8:12920–33.
Xu R, Zhang K, Liu P, Han HW, Zhao S, Kakade A, Khan A, Du DL, Li XK. Lignin depolymerization and utilization by bacteria. Bioresour Technol. 2018;269:557–66.
Zhao ZM, Liu ZH, Pu YQ, Meng XZ, Xu JF, Yuan JS, Ragauskas AJ. Emerging strategies for modifying lignin chemistry to enhance biological lignin valorization. Chemsuschem. 2020;13:5423–32.
Benner. r, hodson re: thermophilic anaerobic biodegradation of c-14 lignin, c-14 cellulose, and c-14 lignocellulose preparations. Appl. Environ. Microbiol. 1985;50:971–976.
Pereira JH, Heins RA, Gall DL, McAndrew RP, Deng K, Holland KC, Donohue TJ, Noguera DR, Simmons BA, Sale KL, et al. Structural and biochemical characterization of the early and late enzymes in the lignin β-Aryl ether cleavage pathway from Sphingobium sp.SYK-6. J Biol Chem. 2016;291:10228–38.
Sugano Y, Yoshida T. DyP-Type peroxidases: recent advances and perspectives. Int J Mol Sci. 2021;22.
Bricotte L, Chougrani K, Alard V, Ladmiral V, Caillol S. Adhesion theories: A didactic review about a century of progress. Int J Adhes Adhes. 2024;132.
Wang Z, Wan XZ, Wang ST. Bioinspired chemical design to control interfacial wet adhesion. Chem. 2023;9:771–83.
Song TJ, He Z, He H, Wang TT, Du J, Lv YN, Tao YH, Lu J, Fu CL, Hu JW, Wang HS. Alkali lignin-Fe(III)-induced successive redox reaction triggered ultrafast gelation of high quality hydrogel for wearable flexible sensors and self-powered devices. Chem Eng J. 2024;500.
Hou Y, Li YZ, Li YQ, Li D, Guo TL, Deng X, Zhang HP, Xie CM, Lu X. Tuning water-resistant networks in mussel-inspired hydrogels for robust wet tissue and bioelectronic adhesion. ACS Nano. 2023;17:2745–60.
Cao JF, Zhao YN, Jin SC, Li JZ, Wu P, Luo ZQ. Flexible lignin-based hydrogels with self-healing and adhesive ability driven by noncovalent interactions. Chem Eng J. 2022;429.
Ghaffar SH, Fan MZ. Lignin in straw and its applications as an adhesive. Int J Adhes Adhes. 2014;48:92–101.
Luo J, Luo JL, Yuan C, Zhang W, Li JZ, Gao Q, Chen H. An eco-friendly wood adhesive from soy protein and lignin: performance properties. RSC Adv. 2015;5:100849–55.
Roy T, James BD, Allen JB. Anti-VEGF-R2 aptamer and RGD peptide synergize in a bifunctional hydrogel for enhanced angiogenic potential. Macromol Biosci. 2021;21.
Wang X, Li X, Peng L, Han S, Hao C, Jiang C, Wang H, Fan X. Effective removal of heavy metals from water using porous lignin-based adsorbents. Chemosphere. 2021;279:130504.
Santos OSH, da Silva MC, Silva VR, Mussel WN, Yoshida MI. Polyurethane foam impregnated with lignin as a filler for the removal of crude oil from contaminated water. J Hazard Mater. 2017;324:406–13.
Domínguez-Robles J, Peresin MS, Tamminen T, Rodríguez A, Larrañeta E, Jääskeläinen AS. Lignin-based hydrogels with super-swelling capacities for dye removal. Int J Biol Macromol. 2018;115:1249–59.
Zhang HN, Fu TT, Zhu YC, Hao C, Huang Y, Ren H, Yan N, Zhai HM. Robust and ultra-tough lignocellulosic organogel with zipper-like sliding noncovalent nanostructural design: towards next-generation bio-derived flexible electronics. Chem Eng J. 2024;485.
Alaoui CH, Rethoré G, Weiss P, Fatimi A. Sustainable biomass lignin-based hydrogels: A review on properties, formulation, and biomedical applications. Int J Mol Sci. 2023;24.
Yan G, He S, Ding N, Lee Y, Sun Y, Tang X, Zeng X, Lin L. Rapid polymerization of conductive hydrogels with multifunctionality initiated by lignin-tin organometallic compounds. Mater Today Chem. 2022;23.
Cao YX, Yang MQ, Zhang R, Ning X, Zong MR, Liu XM, Li JD, Jing X, Li B, Wu XP. Carbon dot-based photo-cross-linked gelatin methacryloyl hydrogel enables dental pulp regeneration: A preliminary study. ACS Appl Mater Interfaces. 2024;16:22976–88.
Yang H, Ghiassinejad S, van Ruymbeke E, Fustin CA. Tunable interpenetrating polymer network hydrogels based on dynamic covalent bonds and metal-ligand bonds. Macromolecules. 2020;53:6956–67.
Chen WX, Ming Y, Wang M, Huang MS, Liu HY, Huang YS, Huang ZJ, Qing L, Wang Q, Jia B. Nanocomposite hydrogels in regenerative medicine: applications and challenges. Macromol Rapid Commun. 2023;44.
Abdullah T, Ilyasoglu G, Memic A. Designing lignin-based biomaterials as carriers of bioactive molecules. Pharmaceutics. 2023;15.
Huzyan HI, Aziz AA, Hussin MH. Ecofriendly wood adhesives from date palm fronds lignin for plywood. BioResources. 2021;16:4106–25.
Yiamsawas D, Kangwansupamonkon W, Kiatkamjornwong S. Lignin-based nanogels for the release of payloads in alkaline conditions. Eur Polym J. 2021;145.
Zhong W, Su WT, Li PH, Li KY, Wu WJ, Jiang B. Preparation and research progress of lignin-based supercapacitor electrode materials. Int J Biol Macromol. 2024;259.
Rico-García D, Ruiz-Rubio L, Pérez-Alvarez L, Hernández-Olmos SL, Guerrero-Ramírez GL, Vilas-Vilela JL. Lignin-based hydrogels: synthesis and applications. Polymers. 2020;12.
Steck J, Yang J, Suo Z. Covalent topological adhesion. ACS Macro Lett. 2019;8:754–8.
Lee SY, Lee J, Song Y, Valtiner M, Lee DW. pH-Dependent interaction mechanism of lignin nanofilms. Nanoscale. 2021;13:19568–77.
Chandna S, Paul S, Kaur R, Gogde K, Bhaumik J. Photodynamic lignin hydrogels: A versatile self-healing platform for sustained release of photosensitizer nanoconjugates. ACS Appl Polym Mater. 2022;4:8962–76.
Li WW, Cheng GG, Wang SJ, Jiang Y, Liu XY, Huang Q. Bifunctional lignocellulose nanofiber hydrogel possessing intriguing pH-responsiveness and self-healing capability towards wound healing applications. Int J Biol Macromol. 2024;260.
Zhu JH, Luo YW, Wang JX, Yu J, Liu Q, Liu JY, Chen RR, Liu PL, Wang J. Highly efficient uranium extraction by aminated lignin-based thermo-responsive hydrogels. J Mol Liq. 2022;368.
Chiani E, Beaucamp A, Hamzeh Y, Azadfallah M, Thanusha AV, Collins MN. Synthesis and characterization of gelatin/lignin hydrogels as quick release drug carriers for ribavirin. Int J Biol Macromol. 2023;224:1196–205.
Jiang YH, Chen YY, Tian D, Shen FY, Wan X, Xu L, Chen YC, Zhang HZ, Hu JG, Shen F. Fabrication and characterization of lignin-xylan hybrid nanospheres as pesticide carriers with enzyme-mediated release property. Soft Matter. 2020;16:9083–93.
Huang JL, Leng KY, Chen YQ, Chen LY, Liu SH, Khan S, Wu DC, Fu RW. An interfacial crosslinking strategy to fabricate an ultrathin two-dimensional composite of silicon oxycarbide-enwrapped silicon nanoparticles for high-performance lithium storage. J Mater Chem A. 2019;7:22950–7.
Spicher MT, Schwaminger SP, von der Haar-Leistl D, Fellenberg E, Berensmeier S. Process development for pilot-scale spray drying of ultrasmall iron (oxyhydr)oxide nanoparticles. Powder Technol. 2024;433.
Li NN, Panagiotopoulos AZ, Nikoubashman A. Structured nanoparticles from the self-assembly of polymer blends through rapid solvent exchange. Langmuir. 2017;33:6021–8.
Chen LH, Luo SM, Huo CM, Shi YF, Feng J, Zhu JY, Xue W, Qiu XQ. New insight into lignin aggregation guiding efficient synthesis and functionalization of a lignin nanosphere with excellent performance. Green Chem. 2022;24:285–94.
Ortega-Sanhueza I, Girard V, Ziegler-Devin I, Chapuis H, Brosse N, Valenzuela F, Banerjee A, Fuentealba C, Cabrera-Barjas G, Torres C et al. Preparation and characterization of lignin nanoparticles from different plant sources. Polymers. 2024;16.
Zhang JW, Tian ZJ, Ji XX, Zhang FS. Fabrication mechanisms of lignin nanoparticles and their ultraviolet protection ability in PVA composite film. Polymers. 2022;14.
Jergens E, de Araujo Fernandes-Junior S, Cui Y, Robbins A, Castro CE, Poirier MG, Gurcan MN, Otero JJ, Winter JO. DNA-caged nanoparticles via electrostatic self-assembly. Nanoscale. 2023;15:9390–402.
Yang YY, Xu JY, Zhou JH, Wang X. Preparation, characterization and formation mechanism of size-controlled lignin nanoparticles. Int J Biol Macromol. 2022;217:312–20.
Singh G, Das K, Mandal DD. Valorization of kraft lignin via its conversion into lignin nanoparticles to act both as DDS and biostimulator for plant. Waste Biomass Valorization. 2024;15:4823–38.
Meng TT, Ding Y, Liu Y, Xu L, Mao YM, Gelfond J, Li SK, Li ZH, Salipante PF, Kim H, et al. In situ lignin adhesion for high-performance bamboo composites. Nano Lett. 2023;23:8411–8.
Jiang WZ, Zhang YC, Yang DJ, Qiu XQ, Li ZX. Ultrasonic-assisted synthesis of lignin-based ultrasmall silver nanoparticles for photothermal-mediated sterilization. Int J Biol Macromol. 2024;262.
Yang ZM, Zhou ZW, Li YQ, Zhu LC, Chen JW, Cheng JW, Su JM, Zhuang ZX, Ning ZB, Yu QS, et al. Assessing the potential of new lignin-based pH-responsive nanoparticles as drug carriers for cancer treatment. ACS Sustain Chem Eng. 2022;10:10590–603.
Siddiqui L, Bag J, Mittal D, Leekha A, Mishra H, Mishra M, Verma AK, Mishra PK, Ekielski A, Iqbal Z, Talegaonkar S. Assessing the potential of lignin nanoparticles as drug carrier: synthesis, cytotoxicity and genotoxicity studies. Int J Biol Macromol. 2020;152:786–802.
Porto DD, Estevao BM, Lins PMP, Rissi NC, Zucolotto V, da Silva M. Orange trunk waste-based lignin nanoparticles encapsulating Curcumin as a photodynamic therapy agent against liver cancer. ACS Appl Polym Mater. 2021;3:5061–72.
Ren CH, Zhou ZS, Cao SM, Jiao MT, Xue DY. Study on the adsorption deformation of a substrate via spin coating based on the 3D-DIC method and its effect on the homogeneity of perovskite films. Materials. 2023;16.
Zhang JJ, Yang P, Peng W, Dong HL, Li LX. The effect of thickness on the optical and electrical properties of hf doped indium oxide thin films. Vacuum. 2023;216.
He Y, Chen Q, Zhang YJ, Zhao YP, Chen L. H2O2-triggered rapid deposition of poly(caffeic acid) coatings: A mechanism-based entry to versatile and high-efficient molecular separation. ACS Appl Mater Interfaces. 2020;12:52104–15.
Debeaufort F, Martinpolo M, Voilley A. Polarity homogeneity and structure affect water-vapor permeability of model edible films. J Food Sci. 1993;58:426–429.
Xu YX, Rehmani N, Alsubaie L, Kim C, Sismour E, Scales A. Tapioca starch active nanocomposite films and their antimicrobial effectiveness on ready-to-eat chicken meat. Food Packag Shelf Life. 2018;16:86–91.
Bai XJ, Chen D, Li LL, Shao L, He WX, Chen H, Li YN, Zhang XM, Zhang LY, Wang TQ, et al. Fabrication of MOF thin films at miscible liquid-liquid interface by spray method. ACS Appl Mater Interfaces. 2018;10:25960–6.
Xia YM, Yu XQ, He ZM, Lu YL, Zhang YF, Sun SP, Zhu SQ, Li XP. Synthesis of novel copper-based oxide nanostructured film on copper via solution-immersion. Ceram Int. 2017;43:14499–503.
Tyuftin AA, Kerry JP. Gelatin films: study review of barrier properties and implications for future studies employing biopolymer films. Food Packag Shelf Life. 2021;29.
Han ML, Zhang Y, Zhang Y, Ye Q, Sillanpää M, Zhu XL, Yang WJ. A mini-review on Polyvinyl alcohol/lignin (nano)composites: preparation, applications and perspectives. Sustainable Chem Pharm. 2024;42.
Zhang JW, Zhang KL, Tian C, Zhang GY, Jiang X, Wang K, Sun K, Jiang JC. Different lignin fraction extraction by pH fractionation for lignin microspheres Preparation as UV-blocking PVA film. Int J Biol Macromol. 2025;311.
Zhang XX, Li G, Chen C, Fan HX, Fang J, Wu XJ, Qi JJ, Li H. Chitosan/PVA composite film enhanced by zno/lignin with high-strength and antibacterial properties for food packaging. Int J Biol Macromol. 2025;306.
Yang ZD, Li J, Jiang CL, Li BY, Guo YL, Wang YW, Zhao JN. Technical and experimental studies on the Preparation of lignin/pva specially shaped carbon electrodes based on frozen DIW technology. Diam Relat Mater. 2025;155.
Karimah A, Wistara NJ, Fatriasari W, Hussin MH. Novel approach: lignin extraction from sequentially pretreated sugarcane trashes to produce prospective nanolignin/pva biosurfactants. Int J Biol Macromol. 2025;316:144425.
Duan WL, Bian XB, Bu YZ. Applications of bioadhesives: A mini review. Front Bioeng Biotechnol. 2021;9.
Li JH, Yu X, Martinez EE, Zhu JQ, Wang T, Shi SW, Shin SR, Hassan S, Guo CC. Emerging biopolymer-based bioadhesives. Macromol Biosci. 2022;22.
Isnard F, Mulunda MM, Rubens M, Marien H, Harumashi T, Wakabayashi K, Vanbroekhoven K, Eevers W, Peeters L, Vendamme R. Stabilization of hybrid adhesives and sealants by thermodynamic tuning of molecularly optimized lignin bio-additives: small changes, big effects. Biomacromolecules. 2022;23:3174–85.
Du BY, Li WJ, Zhu HW, Xu JY, Wang QY, Shou XL, Wang X, Zhou JH. A functional lignin for heavy metal ions adsorption and wound care dressing. Int J Biol Macromol. 2023;239.
Wijaya CJ, Ismadji S, Gunawan S. A review of lignocellulosic-derived nanoparticles for drug delivery applications: lignin nanoparticles, Xylan nanoparticles, and cellulose nanocrystals. Molecules. 2021;26.
Xu C, Liu LY, Renneckar S, Jiang F. Chemically and physically crosslinked lignin hydrogels with antifouling and antimicrobial properties. Ind Crops Prod. 2021;170.
Nguyen HM, Le TTN, Nguyen AT, Le HNT, Pham TT. Biomedical materials for wound dressing: recent advances and applications. RSC Adv. 2023;13:5509–28.
Kharaziha M, Scheibel T, Salehi S. Multifunctional naturally derived bioadhesives: from strategic molecular design toward advanced biomedical applications. Prog Polym Sci. 2024;150.
Legrand JMD, Martino MM. Growth factor and cytokine delivery systems for wound healing. Cold Spring Harb Perspect Biol. 2022;14.
Dai ZW, Li J, Lin YF, Wang ZG, Huang Y. Facile construction of a solely-DNA-based system for targeted delivery of nucleic acids. Nanomaterials. 2021;11.
Zhu HC, Luo H, Chang RL, Yang YF, Liu DK, Ji Y, Qin H, Rong HB, Yin J. Protein-based delivery systems for RNA delivery. J Control Release. 2023;363:253–74.
Liu X, Huang KK, Zhang FX, Huang G, Wang L, Wu GY, Ren H, Yang G, Lin ZQ. Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases. J Nanobiotechnol. 2024;22.
Maqsoudlou A, Assadpour E, Mohebodini H, Jafari SM. The influence of nanodelivery systems on the antioxidant activity of natural bioactive compounds. Crit Rev Food Sci Nutr. 2022;62:3208–31.
Fadaka AO, Sibuyi NRS, Madiehe AM, Meyer M. Nanotechnology-based delivery systems for antimicrobial peptides. Pharmaceutics. 2021;13.
Yu HL, Yang ZH, Li F, Xu LS, Sun Y. Cell-mediated targeting drugs delivery systems. Drug Deliv. 2020;27:1425–37.
Ivanova D, Nikolova G, Karamalakova Y, Semkova S, Marutsova V, Yaneva Z. Water-soluble alkali lignin as a natural radical scavenger and anticancer alternative. Int J Mol Sci. 2023;24.
Tsuji R, Ikado K, Fujiwara D. Modulation of innate immunity by lignin-carbohydrate, a novel TLR4 ligand, results in augmentation of mucosal IgA and systemic IgG production. Int J Mol Sci. 2018;19.
Wang YL, Li ZX, Yang DJ, Qiu XQ, Xie YX, Zhang X. Microwave-mediated fabrication of silver nanoparticles incorporated lignin-based composites with enhanced antibacterial activity via electrostatic capture effect. J Colloid Interface Sci. 2021;583:80–8.
Liang RM, Yang XC, Yew PYM, Sugiarto S, Zhu Q, Zhao JM, Loh XJ, Zheng L, Kai D. PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment. J Nanobiotechnol. 2022;20.
Trinh TA, Nguyen TL, Kim J. Lignin-based antioxidant hydrogel patch for the management of atopic dermatitis by mitigating oxidative stress in the skin. ACS Appl Mater Interfaces. 2024.
Lin DR, Xiao LJ, Qin W, Loy DA, Wu ZJ, Chen H, Zhang Q. Preparation, characterization and antioxidant properties of Curcumin encapsulated chitosan/lignosulfonate micelles. Carbohydr Polym. 2022, 281.
Xun Y, Yang H, Kaminska B, You H. Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma. J Hematol Oncol. 2021;14.
Slavin YN, Ivanova K, Hoyo J, Perelshtein I, Owen G, Haegert A, Lin YY, LeBihan S, Gedanken A, Häfeli UO, et al. Novel lignin-capped silver nanoparticles against multidrug-resistant bacteria. ACS Appl Mater Interfaces. 2021;13:22098–109.
Amini S, Saudi A, Amirpour N, Jahromi M, Najafabadi SS, Kazemi M, Rafienia M, Salehi H. Application of electrospun Polycaprolactone fibers embedding lignin nanoparticle for peripheral nerve regeneration: in vitro and in vivo study. Int J Biol Macromol. 2020;159:154–73.
Huang CX, Tang S, Zhang WY, Tao YH, Lai CH, Li X, Yong Q. Unveiling the structural properties of lignin-carbohydrate complexes in bamboo residues and its functionality as antioxidants and immunostimulants. ACS Sustain Chem Eng. 2018;6:12522–31.
Fan XD, Yue TX, Liu AD, Xie XW, Fang WX, Wei YH, Zheng HS, Zheng HY, Zhou MQ, Piao JG, Li FZ. Lignin-assisted construction of sub-10 Nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors. Asian J Pharm Sci. 2022;17:713–27.
Kobayashi Y, Kurose N, Guo X, Shioya A, Kitamura M, Tsuji H, Yamada S. The potential role of follicular helper T cells and helper T cells type 1 in warthin tumour. Pathol Res Pract. 2021;220.
Byrne CE, Astete CE, Vaithiyanathan M, Melvin AT, Moradipour M, Rankin SE, Knutson BL, Sabliov CM, Martin EC. Lignin-graft-PLGA drug-delivery system improves efficacy of MEK1/2 inhibitors in triple-negative breast cancer cell line. Nanomedicine. 2020;15:981–1000.
Zheng Z, Zhang HS, Qian K, Li L, Shi DW, Zhang R, Li L, Yu HB, Zheng CS, Xie SX et al. Wood structure-inspired injectable lignin-based nanogels as blood-vessel-embolic sustained drug-releasing stent for interventional therapies on liver cancer. Biomaterials. 2023;302.
Cui MH, Li SQ, Ma XZ, Wang JG, Wang XL, Chen J, Zhu J, Chen J. Sustainable Janus lignin-based polyurethane biofoams with robust antibacterial activity and long-term biofilm resistance. Int J Biol Macromol. 2024;256.
Pei WH, Yusufu Y, Zhan YF, Wang XC, Gan J, Zheng LM, Wang P, Zhang K, Huang CX. Biosynthesizing lignin dehydrogenation polymer to fabricate hybrid hydrogel composite with hyaluronic acid for cartilage repair. Adv Compos Hybrid Mater. 2023;6.
Xue YY, Liang WS, Li Y, Wu Y, Peng XW, Qiu XQ, Liu JB, Sun RC. Fluorescent pH-sensing probe based on biorefinery wood lignosulfonate and its application in human cancer cell bioimaging. J Agric Food Chem. 2016;64:9592–600.
Demirci-Çekiç S, Özkan G, Avan AN, Uzunboy S, Çapanoglu E, Apak R. Biomarkers of oxidative stress and antioxidant defense. J Pharm Biomed Anal. 2022;209.
Mu KW, Kitts DD. Intestinal polyphenol antioxidant activity involves redox signaling mechanisms facilitated by Aquaporin activity. Redox Biol. 2023;68.
Gebicki JM, Nauser T. Fast antioxidant reaction of polyphenols and their metabolites. Antioxidants. 2021;10.
Saeed I, Guo XB, Azeem M, Elshikh MS, Zainab BB, Ayaz Z, You LJ, Alwahibi MS, Abbasi AM. Comparative assessment of polyphenolics’ content, free radicals’ scavenging and cellular antioxidant potential in apricot fruit. J King Saud Univ Sci. 2021;33.
Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2010;302:71–83.
Rumpf J, Burger R, Schulze M. Statistical evaluation of DPPH, ABTS, FRAP, and Folin-Ciocalteu assays to assess the antioxidant capacity of lignins. Int J Biol Macromol. 2023;233.
Ponomarenko J, Dizhbite T, Lauberts M, Volperts A, Dobele G, Telysheva G. Analytical pyrolysis—A tool for revealing of lignin structure-antioxidant activity relationship. J Anal Appl Pyrol. 2015;113:360–9.
Liang RM, Zhao JM, Li B, Cai PA, Loh XJ, Xu CH, Chen P, Kai D, Zheng L. Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment. Biomaterials. 2020;230.
Kim SH, Lam PY, Lee MH, Jeon HS, Tobimatsu Y, Park OK. The Arabidopsis R2R3 MYB transcription factor MYB15 is a key regulator of lignin biosynthesis in effector-triggered immunity. Front Plant Sci. 2020;11.
Liu T, Shen HL, Wang FR, Zhou XR, Zhao PT, Yang YL, Guo YR. Thinned-young Apple polyphenols inhibit halitosis-related bacteria through damage to the cell membrane. Front Microbiol. 2022;12.
Peng F, Chen LA, Wang XP, Yu ZQ, Cheng CH, Yang YD. Effect of chestnut (Castanea mollissima Blume) Bur polyphenol extract on Shigella dysenteriae: antibacterial activity and the mechanism. Molecules. 2023;28.
Ravera S, Tancreda G, Vezzulli L, Schito AM, Panfoli I. Cirsiliol and Quercetin inhibit ATP synthesis and decrease the energy balance in methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from patients. Molecules. 2023;28.
Wang N, Liu XY, Ma Y, Huang XQ, Song LJ, Guo HT, Sun XD, Sun XY, Hai D, Zhao PJ, Shen Y. Identification of polyphenol extracts from flaxseed and study on its bacteriostatic mechanism. Food Biosci. 2024;58.
Matos M, Claro FC, Lima TAM, Avelino F, Hansel FA, Maciel GM, Lomonaco D, Magalhaes WLE. Acetone: water fractionation of pyrolytic lignin improves its antioxidant and antibacterial activity. J Anal Appl Pyrol. 2021;156.
You SH, Xie YG, Zhuang XS, Chen HY, Qin YY, Cao JX, Lan TQ. Effect of high antioxidant activity on bacteriostasis of lignin from sugarcane Bagasse. Biochem Eng J. 2022;180.
Honing DY, Luiten RM, Matos TR. Regulatory T cell dysfunction in autoimmune diseases. Int J Mol Sci. 2024;25.
da Cruz IJ, Barros BRD, Aguiar LMD, Navarro CDC, Ruas JS, de Lorena VMB, Rocha GJD, Vercesi AE, de Melo CML, Maior AMS. Lignins isolated from prickly Pear cladodes of the species Opuntia ficus-indica (Linnaeus) miller and Opuntia cochenillifera (Linnaeus) miller induces mice splenocytes activation, proliferation and cytokines production. Int J Biol Macromol. 2019;123:1331–9.
Kaliyamoorthy V, Jacop JP, Thirugnanasambantham K, Ibrahim HIM, Kandhasamy S. The synergic impact of lignin and Lactobacillus plantarum on DSS-induced colitis model via regulating CD44 and MiR 199a alliance. World J Microbiol Biotechnol. 2022;38.
Santos D, Barros BRD, Aguiar LMD, da Cruz IJ, de Lorena VMB, de Melo CML, Napoleao TH. Immunostimulatory and antioxidant activities of a lignin isolated from Conocarpus erectus leaves. Int J Biol Macromol. 2020;150:169–77.
Ciliberti MG, Albenzio M, De Palo P, Santillo A, Caroprese M. Nexus between immune responses and oxidative stress: the role of dietary hydrolyzed lignin in ex vivo bovine peripheral blood mononuclear cell response. Front Vet Sci. 2020;7.
de Melo CML, da Cruz IJ, de Sousa GF, Silva GAD, Santos D, da Silva RS, de Sousa BR, de Lima RG, de Lima MDA, Rocha GJD. Lignin isolated from Caesalpinia pulcherrima leaves has antioxidant, antifungal and immunostimulatory activities. Int J Biol Macromol. 2020;162:1725–33.
Lu FY, Ni SZ, Meng XX, Si CL, Qin MH, Wang Y, Fu YJ, Chen XQ. Preparation of pH-sensitive lignin nanoparticles and its application in hydrophobic drug delivery. Ind Crops Prod. 2023;202.
Yi CH, Xu QH, Yang DJ, Wang M. A novel pH-responsive charge reversal nanospheres based on acetylated histidine-modified lignin for drug delivery. Ind Crops Prod. 2022;186.
Pham CD, Truong TM, Ly TB, Le PK. Application of lignin from cellulose isolation process in the fabrication of chitosan/lignin film for UV-light blocking and anti-oxidation. Waste Biomass Valorization. 2024;15:1881–94.
Nugroho RA, Saputra OA, Pradita AL, Fajar AN, Wibowo FR. Lignin-based polyurethane composites enhanced with hydroxyapatite for controlled drug delivery and potential cellular scaffold applications. Polym Compos. 2024.
Zou JF, Bao DD, Ma R, Zhu ZH, Chen XJ, Zhu JJ, Fan XD, Zhang K, Zheng HY, Li FZ, Piao JG. Green and sustainable self-assembly nanocomposite from gentamicin sulfate/lignosulfonate with efficient antibacterial and wound-healing activity. ACS Sustain Chem Eng. 2020;8:4931–40.
Zhao CK, Yang JL, Chen MF, Chen WJ, Yang XY, Ye H, Wang LY, Wang Y, Shi JJ, Yue FX, Ma X. Synthetic lignin-derived therapeutic nano reagent as intestinal pH-sensitive drug carriers capable of bypassing the gastric acid environment for colitis treatment. ACS Nano. 2023;17:811–24.
Wang M, Yang DJ, Xu QH, Li PS, Yi CH, Qian Y, Qiu XQ. Highly efficient evaporation method to prepare pH-responsive lignin-hollow-nanosphere with controllable size and its application in oral drug delivery. Ind Crops Prod. 2021;162.
Cheng LH, Deng B, Luo WH, Nie SF, Liu XY, Yin YN, Liu SB, Wu ZP, Zhan P, Zhang L, Chen JN. pH-Responsive lignin-based nanomicelles for oral drug delivery. J Agric Food Chem. 2020;68:5249–58.
Wang YL, Lu ZQ, Liu B, Seidi F, Zhang CF, Jiang B, Huang CX, Xiao HN, Wang P, Jin YC. Antitumor effects of carrier-free functionalized lignin materials on human hepatocellular carcinoma (HepG2) cells. ACS Nano. 2024;18:4329–42.
Li YY, Qiu XQ, Qian Y, Xiong WL, Yang DJ. pH-responsive lignin-based complex micelles: preparation, characterization and application in oral drug delivery. Chem Eng J. 2017;327:1176–83.
Spiridon I, Andrei IM, Anghel N, Dinu MV, Ciubotaru BI. Development and characterization of novel cellulose composites obtained in 1-ethyl-3-methylimidazolium chloride used as drug delivery systems. Polymers. 2021;13.
Anghel N, Dinu VM, Verestiuc L, Spiridon IA. Transcutaneous drug delivery systems based on collagen/polyurethane composites reinforced with cellulose. Polymers. 2021;13.
Pishnamazi M, Iqbal J, Shirazian S, Walker G, Collins M. Effect of lignin as natural polymer on the release rate of acetylsalicylic acid tablets. Int J Biol Macromol. 2018;124.
Domínguez-Robles J, Stewart SA, Rendl A, González Z, Donnelly RF, Larrañeta E. Lignin and cellulose blends as pharmaceutical excipient for tablet manufacturing via direct compression. Biomolecules. 2019;9.
Pishnamazi M, Hafizi H, Shirazian S, Culebras M, Walker GM, Collins MN. Design of controlled release system for Paracetamol based on modified lignin. Polymers. 2019;11.
Kumar R, Butreddy A, Kommineni N, Reddy PG, Bunekar N, Sarkar C, Dutt S, Mishra VK, Aadil KR, Mishra YK, et al. Lignin: drug/gene delivery and tissue engineering applications. Int J Nanomed. 2021;16:2419–41.
Bao GY, Gao QM, Cau M, Ali-Mohamad N, Strong M, Jiang SB, Yang Z, Valiei A, Ma ZW, Amabili M et al. Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage. Nat Commun. 2022;13.
Li J, Xu X, Ma X, Cui M, Wang X, Chen J, Zhu J, Chen J. Antimicrobial nonisocyanate polyurethane foam derived from lignin for wound healing. ACS Appl Bio Mater. 2024;7:1301–10.
Yuan Y, Wang SX, Wu P, Yuan TQ, Wang XL. Lignosulfonate in situ-modified reduced graphene oxide biosensors for the electrochemical detection of dopamine. RSC Adv. 2022;12:31083–90.
Guan XW, Li ZX, Geng X, Lei ZH, Karakoti A, Wu TM, Kumar P, Yi JB, Vinu A. Emerging trends of carbon-based quantum dots: nanoarchitectonics and applications. Small. 2023;19.
Paul S, Thakur NS, Chandna S, Sagar V, Bhaumik J. Lignin-based cds Dots as multifunctional platforms for sensing and wearable photodynamic coatings. ACS Appl Nano Mater. 2022;5.
Zhang JX, Jin JH, Wan JQ, Jiang SH, Wu YZ, Wang WF, Gong X, Wang HX. Quantum dots-based hydrogels for sensing applications. Chem Eng J. 2021;408.
Wang QH, Pan XF, Lin CM, Lin DZ, Ni YH, Chen LH, Huang LL, Cao SL, Ma XJ. Biocompatible, self-wrinkled, antifreezing and stretchable hydrogel-based wearable sensor with pedot:sulfonated lignin as conductive materials. Chem Eng J. 2019;370:1039–47.
Zhang Y, Cheng G. Lignin-containing hydrogels: transforming a low-value byproduct to absorbents, wound dressings and strain sensors. Chem Eng J. 2023;475.
Mohanadas D, Rohani R, Sulaiman Y, Abu Bakar S, Mahmoudi E, Zhang LC. Heavy metal detection in water using MXene and its composites: A review. Mater Today Sustain. 2023;22.
Lu H, Zhu HT, Xu JH, Lai XJ, Zeng XR, Li HQ. Biobased, degradable and directional porous carboxymethyl chitosan/lignosulfonate sodium aerogel-based piezoresistive pressure sensor with dual-conductive network for human motion detection. Chem Eng J. 2024;497.
Abbadessa A, Dogaris I, Farahani SK, Reid MS, Rautkoski H, Holopainen-Mantila U, Oinonen P, Henriksson G. Layer-by-layer assembly of sustainable lignin-based coatings for food packaging applications. Prog Org Coat. 2023;182.
Zhang GG, Tian CR, Shi JW, Zhang X, Liu J, Tan TW, Zhang LQ. Mechanically robust, self-repairable, shape memory and recyclable ionomeric elastomer composites with renewable lignin via interfacial metal-ligand interactions. ACS Appl Mater Interfaces. 2022;14:38216–27.
Yang YT, Zhu YC, Yang A, Liu T, Fang YQ, Wang WH, Song YM, Li Y. Rapid fabricated in-situ polymerized lignin hydrogel sensor with highly adjustable mechanical properties. Int J Biol Macromol. 2024;260.
Yang XJ, Wang XR, Wang X, Li XK, Xin HW, Zhou JH, Sun DY. Utilization of composite particles with customizable cross-linked lignin patches for dental cleansing. Int J Biol Macromol. 2024;266.
Ying M, Zeng ZY, Li Q, Chen XL, Xiong Y, Wu B, Peng L, Zhang Q, Wang L, Dai ZM, et al. Water-soluble intracellular extract of desmodesmus sp. YT enhanced the antioxidant capacity of human skin fibroblast to protect the skin from UV damage. J Cosmet Dermatol. 2024;23:1850–61.
Sjovall P, Christensen OB, Moller H. Single exposure to ultraviolet irradiation and elicitation of human allergic contact dermatitis. Acta Derm Venereol. 1985;65:93–6.
Brand RM, Stottlemyer JM, Paglia MC, Carey CD, Falo LD. Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction. J Dermatol Sci. 2021;101:40–8.
van Bodegraven M, Kröger M, Díaz DFZ, Lohan SB, Moritz RKC, Möller N, Knoblich C, Vogelsang A, Milinic Z, Hallhuber M et al. Redefine photoprotection: sun protection beyond sunburn. Exp Dermatol. 2024;33.
Lin MS, Yang LJ, Zhang H, Xia Y, He Y, Lan W, Ren JL, Yue FX, Lu FC. Revealing the structure-activity relationship between lignin and anti-UV radiation. Ind Crops Prod. 2021;174.
Javed A, Rättö P, Järnström L, Ullsten H. Lignin-containing coatings for packaging materials—Pilot trials. Polymers. 2021;13.
Boarino A, Klok HA. Opportunities and challenges for lignin valorization in food packaging, antimicrobial, and agricultural applications. Biomacromolecules. 2023;24:1065–77.
Xiao LQ, Zhang XJ, Fu QL, Xu PW, Liu TX, Wang ZY, Yang WJ, Ma PM. One step to simultaneously improve the antibacterial activity and compatibility with PBAT of nanolignin via surface modification. ACS Sustain Chem Eng. 2023;11:14773–81.
Daassi R, Durand K, Rodrigue D, Stevanovic T. Optimization of the electrospray process to produce lignin nanoparticles for PLA-based food packaging. Polymers. 2023;15.
Lee WJ, Oh HG, Cha SH. A brief review of self-healing polyurethane based on dynamic chemistry. Macromol Res. 2021;29:649–64.
Lu W, Le XX, Zhang JW, Huang YJ, Chen T. Supramolecular shape memory hydrogels: A new Bridge between stimuli-responsive polymers and supramolecular chemistry. Chem Soc Rev. 2017;46:1284–94.
Liu WF, Fang C, Chen FT, Qiu XQ. Strong, reusable, and self-healing lignin-containing polyurea adhesives. Chemsuschem. 2020;13:4691–701.
Du JH, Wang H, Huang ZY, Liu XC, Yin XS, Wu JX, Lin WJ, Lin XF, Yi GB. Construction and mechanism study of lignin-based polyurethane with high strength and high self-healing properties. Int J Biol Macromol. 2023;248.
Prathumrat P, Nikzad M, Shireen Z, Hajizadeh E, Sbarski I. A combined experimental and molecular dynamic studies of curing of shape memory lignin-liquid crystalline elastomeric composites. Compos Sci Technol. 2023;240.
Yuan WH, Zhou J, Jiang MY, Sun QF, Ye GY, Zhang XC, Bi HJ. Latent fingerprints identification and ink-free printing of fluorescent lignin-derived cds/pva nanocomposite with multi-stimuli responsive shape memory behavior. Ind Crops Prod. 2023;205.
Meng D, Zhao QL, Cheng XY, Ma JH, Kong LY, He XH, Li JW. Water-induced shape memory cellulose nanofiber-based nanocomposite membrane containing lignin with quick water response and excellent wet mechanical property. Eur Polym J. 2022;171.
Xue BL, Tang R, Xue DW, Guan Y, Sun YC, Zhao W, Tan JJ, Li XP. Sustainable alternative for bisphenol A epoxy resin high-performance and recyclable lignin-based epoxy vitrimers. Ind Crops Prod. 2021;168.
Wang F, Jiang M, Pan Y, Lu Y, Xu WJ, Zhou YF. 3D printing photo-induced lignin nanotubes/polyurethane shape memory composite. Polym Test. 2023;119.
Abudula T, Colombani T, Alade T, Bencherif SA, Memic A. Injectable Lignin-co-Gelatin cryogels with antioxidant and antibacterial properties for biomedical applications. Biomacromolecules. 2021;22:4110–21.
Wei XX, Liu Y, Luo YD, Shen Z, Wang SF, Li MF, Zhang LM. Effect of organosolv extraction on the structure and antioxidant activity of Eucalyptus kraft lignin. Int J Biol Macromol. 2021;187:462–70.
Gu Y, Ye M, Wang Y, Li H, Zhang H, Wang G, Zhang Y, Zhao HJ. Lignosulfonate functionalized g-C3N4/Carbonized wood sponge for highly efficient heavy metal ion scavenging. J Mater Chem A. 2020.
Barman BRV, Kadam P, Kumar R. Lignin-Based adsorbent for effective removal of toxic heavy metals from wastewater. Emerg Mater. 2022;5:923–43.
Yang XH, Li Z, Li L, Li N, Jing F, Hu LH, Shang QQ, Zhang X, Zhou YH, Pan XJ. Depolymerization and demethylation of kraft lignin in molten salt hydrate and applications as an antioxidant and metal ion scavenger. J Agric Food Chem. 2021;69:13568–77.
Dai K, Zhao GL, Kou JW, Wang ZC, Zhang J, Wu JL, Yang PP, Li M, Tang CL, Zhuang W, Ying HJ. Magnetic mesoporous sodium citrate modified lignin for improved adsorption of calcium ions and methylene blue from aqueous solution. J Environ Chem Eng. 2021;9.
Ding W, Sun H, Li XZ, Li YY, Jia HT, Luo YL, She D, Geng ZC. Environmental applications of Lignin-Based hydrogels for Cu remediation in water and soil: adsorption mechanisms and passivation effects. Environ Res. 2024;250.
