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Home»Nanotechnology»Viral glycoprotein-mimicking peptide-functionalized micelles promote d…
Nanotechnology

Viral glycoprotein-mimicking peptide-functionalized micelles promote d…

Editor-In-ChiefBy Editor-In-ChiefDecember 29, 2025No Comments7 Mins Read
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  • Deng, R. et al. Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis. Sci. Transl. Med. 16, eadh9751 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhou, D. et al. Intra-articular nanodrug delivery strategies for treating osteoarthritis. Drug Discov. Today 28, 103482 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Jones, I. A., Togashi, R., Wilson, M. L., Heckmann, N. & Vangsness, C. T. Jr Intra-articular treatment options for knee osteoarthritis. Nat. Rev. Rheumatol. 15, 77–90 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bedingfield, S. K. et al. Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage. Nat. Biomed. Eng. 5, 1069–1083 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392, 1789–1858 (2018).

    Article 

    Google Scholar
     

  • Hunter, D. J., March, L. & Chew, M. Osteoarthritis in 2020 and beyond: a Lancet Commission. Lancet 396, 1711–1712 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Kim, H. et al. The current state of the osteoarthritis drug development pipeline: a comprehensive narrative review of the present challenges and future opportunities. Ther. Adv. Musculoskel. 14, 1759720X221085952 (2022).

    Article 

    Google Scholar
     

  • Lindström, E. et al. Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711. J. Transl. Med. 16, 1–14 (2018).

    Article 

    Google Scholar
     

  • Mancipe Castro, L., Garcia, A. & Guldberg, R. Biomaterial strategies for improved intra-articular drug delivery. J. Biomed. Mater. Res. A 109, 426–436 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sterner, B. et al. The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage. Eur. J. Pharm. Biopharm. 101, 126–136 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rahimi, M., Charmi, G., Matyjaszewski, K., Banquy, X. & Pietrasik, J. Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis. Acta Biomater. 123, 31–50 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rothenfluh, D., Bermudez, H., O’Neil, C. & Hubbell, J. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat. Mater. 7, 248–254 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ji, M. et al. Precise targeting of miR-141/200c cluster in chondrocytes attenuates osteoarthritis development. Ann. Rheum. Dis. 80, 356–366 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Chen, J. et al. A quick and innovative pipeline for producing chondrocyte-homing peptide-modified extracellular vesicles by three-dimensional dynamic culture of hADSCs spheroids to modulate the fate of remaining ear chondrocytes in the M1 macrophage-infiltrated microenvironment. J. Nanobiotechnol. 22, 300 (2024).

    Article 
    CAS 

    Google Scholar
     

  • Zhou, D. et al. MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis. Bioact. Mater. 37, 378–392 (2024).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Smith, A. E. & Helenius, A. How viruses enter animal cells. Sci. Adv. 304, 237–242 (2004).

    CAS 

    Google Scholar
     

  • Grove, J. & Marsh, M. The cell biology of receptor-mediated virus entry. J. Cell Biol. 195, 1071–1082 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weissenhorn, W. et al. Structural basis for membrane fusion by enveloped viruses. Mol. Membr. Biol. 16, 3–9 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Von der Mark, K. et al. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum. 35, 806–811 (1992).

    Article 
    PubMed 

    Google Scholar
     

  • Knudson, W. & Loeser, R. CD44 and integrin matrix receptors participate in cartilage homeostasis. Cell. Mol. Life Sci. 59, 36–44 (2002).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li, H., Wang, D., Yuan, Y. & Min, J. New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis. Arthritis Res. Ther. 19, 248 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dissanayake, S., Denny, W. A., Gamage, S. & Sarojini, V. Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. J. Control. Release 250, 62–76 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Olson, E. S. et al. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc. Natl Acad. Sci. USA 107, 4311–4316 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jiang, T. et al. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc. Natl Acad. Sci. USA 101, 17867–17872 (2004).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang, H. et al. Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression. Sci. Adv. 9, eabo7868 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schipani, E. et al. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev. 15, 2865–2876 (2001).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, J.-w., Tchernyshyov, I., Semenza, G. L. & Dang, C. V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177–185 (2006).

    Article 
    PubMed 

    Google Scholar
     

  • Stegen, S. et al. HIF-1α metabolically controls collagen synthesis and modification in chondrocytes. Nature 565, 511–515 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bouaziz, W. et al. Interaction of HIF1alpha and beta-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proc. Natl Acad. Sci. USA 113, 5453–5458 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ummarino, D. Hypoxia protects against cartilage loss by regulating Wnt signalling. Nat. Rev. Rheumatol. 12, 315–315 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Philip, M. et al. Metabolic studies of hypoxia-inducible factor stabilisers IOX2, IOX3 and IOX4 (in vitro) for doping control. Drug Test. Anal. 13, 794–816 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stoddart, J. C., Dandridge, O., Garner, A., Cobb, J. & van Arkel, R. J. The compartmental distribution of knee osteoarthritis—a systematic review and meta-analysis. Osteoarthr. Cartil. 29, 445–455 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Wang, Q. et al. Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. JCI Insight 4, e128616 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gao, J. et al. Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs. Trends Pharmacol. Sci. 43, 171–187 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shimomura, S. et al. Mechanical stimulation of chondrocytes regulates HIF-1α under hypoxic conditions. Tissue Cell 71, 101574 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Adesida, A. B. et al. Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture. Arthritis Res. Ther. 9, R69 (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu, Q. et al. Efficient siRNA transfer to knockdown a placenta specific lncRNA using RGD-modified nano-liposome: a new preeclampsia-like mouse model. Int. J. Pharm. 546, 115–124 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mao, X. et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells. Nanomedicine 10, 2677–2695 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wei, Y. et al. Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression. Sci. Adv. 7, eabe6374 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Van den Borne, M. et al. International Cartilage Repair Society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in autologous chondrocyte implantation (ACI) and microfracture. Osteoarthr. Cartil. 15, 1397–1402 (2007).

    Article 

    Google Scholar
     

  • Pritzker, K. P. et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr. Cartil. 14, 13–29 (2006).

    Article 
    CAS 

    Google Scholar
     

  • Little, C. B. et al. The OARSI histopathology initiative—recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthr. Cartil. 18, S80–S92 (2010).

    Article 

    Google Scholar
     

  • Oláh, T. et al. Topographic modeling of early human osteoarthritis in sheep. Sci. Transl. Med. 11, eaax6775 (2019).

    Article 
    PubMed 

    Google Scholar
     



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